Fatal Human Meningoencephalitis due to Halicephalobus Nematodes, Germany
نویسندگان
چکیده
Infections with Halicephalobus nematodes, causative agents of severe meningoencephalitis in horses, have rarely been reported in humans. In this study, the clinical, serological, cytokine, and histopathological findings of a rapidly progressive and eventually fatal meningoencephalitis in a previously healthy human are described. The helminth was finally diagnosed by specific polymerase chain reactions from post mortem tissue.
منابع مشابه
First human case of fatal Halicephalobus gingivalis meningoencephalitis in Australia.
Halicephalobus gingivalis (previously Micronema deletrix) is a free-living nematode known to cause opportunistic infections, mainly in horses. Human infections are very rare, but all cases described to date involved fatal meningoencephalitis. Here we report the first case of H. gingivalis infection in an Australian human patient, confirmed by nematode morphology and sequencing of ribosomal DNA....
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A 6-year-old Thoroughbred gelding was euthanized after a 2-month period of abnormal neurological signs, such as circling left in his pen and hitting his head and body against the wall. After the horse was euthanized on the farm, a half of the brain and whole blood were submitted for diagnostic tests. Histopathological examination of the brain revealed granulomatous and eosinophilic meningoencep...
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Phylogenetic relationships among six isolates of Halicephalobus gingivalis (Stefanski, 1954), a species with pathogenic potential in horses and humans, were evaluated using DNA sequences from the nuclear large-subunit ribosomal RNA (LSU rDNA) gene. Sequences from nematodes obtained from in vitro cultures (soil or clinical sources), or isolated from infected horse tissues, were compared. Gene se...
متن کاملHalicephalobus Infection in a Fatal Case of Encephalomyelitis
A female with encephalitis died 29 days after hospitalization. Histological examination of the brain revealed several nematodes, mostly larva, although a later stage larva/early adult worm was found and was morphologically consistent as being in the genus Halicephalobus. Halicephalobus specific and cephalob nematode specific PCR assays were performed on DNA extracted from unfixed frozen tissues...
متن کاملThe distribution pattern of Halicephalobus gingivalis in a horse is suggestive of a haematogenous spread of the nematode
The majority of Halicephalobus gingivalis-infections in horses have been fatal and are usually not diagnosed before necropsy. Therefore, knowledge about the nematode and the pathogenesis of infection in horses is limited. This has resulted in an on-going discussion about the port of entry and subsequent dissemination of H. gingivalis within the host. The present case of H. gingivalis-infection ...
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